Comparison of Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum.

نویسندگان

  • Siu-Kei Chow
  • Ederlyn E Atienza
  • Linda Cook
  • Harry Prince
  • Patricia Slev
  • Mary Lapé-Nixon
  • Keith R Jerome
چکیده

Serology remains critical for diagnosing hepatitis D virus (HDV) infection, which affects 15 to 20 million people worldwide, but the literature on characterizing commercial enzyme immunoassays (EIAs) dates back to 15 years ago. We evaluated 2 commercial EIAs currently available for detecting anti-HDV antibodies. The DiaSorin assay demonstrated 100% sensitivity and specificity. Using a modified cutoff value, the Cusabio assay demonstrated a sensitivity of 81.3% and specificity of 90.9%. Our data show that recently developed EIAs are reliable for anti-HDV antibody detection.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 23 8  شماره 

صفحات  -

تاریخ انتشار 2016